miR-125a-5p regulates differential activation of macrophages and inflammation

S Banerjee, H Cui, N Xie, Z Tan, S Yang, M Icyuz… - Journal of Biological …, 2013 - ASBMB
Macrophage activation is a central event in immune responses. Macrophages undergoing
classical activation (M1 macrophages) are proinflammatory, whereas alternatively activated
macrophages (M2 macrophages) are generally anti-inflammatory. miRNAs play important
regulatory roles in inflammatory response. However, the manner in which miRNAs regulate
macrophage activation in response to different environmental cues has not been well
defined. In this study, we found that M-BMM macrophages (M2) express greater levels of …