Structure and function of choline kinase isoforms in mammalian cells
C Aoyama, H Liao, K Ishidate - Progress in lipid research, 2004 - Elsevier
Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway
for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from
choline and ATP in the presence of Mg2+. This enzyme exists in mammalian cells as at least
three isoforms that are encoded by two separate genes termed ck-α and ck-β. Each isoform
is not active in its monomeric form. The active enzyme consists of either their homo-or hetero-
dimeric (or oligomeric) forms. In recent years, the roles of CK in cell growth and cell …
for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from
choline and ATP in the presence of Mg2+. This enzyme exists in mammalian cells as at least
three isoforms that are encoded by two separate genes termed ck-α and ck-β. Each isoform
is not active in its monomeric form. The active enzyme consists of either their homo-or hetero-
dimeric (or oligomeric) forms. In recent years, the roles of CK in cell growth and cell …
