[HTML][HTML] Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders
K Reue, H Wang - Journal of lipid research, 2019 - ASBMB
The regulation of cellular lipid storage and membrane lipid composition plays a critical role
in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity,
fatty liver, type 2 diabetes, and cardiovascular disease. The mammalian lipin proteins (lipin
1, lipin 2, and lipin 3) are phosphatidic acid phosphatase (PAP) enzymes that modulate
levels of cellular triacylglycerols and phospholipids, and also regulate lipid intermediates in
cellular signaling pathways. Lipin proteins also have the ability to coactivate/corepress …
in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity,
fatty liver, type 2 diabetes, and cardiovascular disease. The mammalian lipin proteins (lipin
1, lipin 2, and lipin 3) are phosphatidic acid phosphatase (PAP) enzymes that modulate
levels of cellular triacylglycerols and phospholipids, and also regulate lipid intermediates in
cellular signaling pathways. Lipin proteins also have the ability to coactivate/corepress …
