[HTML][HTML] Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway
Lipin-1 catalyzes the formation of diacylglycerol from phosphatidic acid. Lipin-1 mutations
cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated,
and the yeast ortholog Pah1p becomes membrane-associated and active upon
dephosphorylation by the Nem1p-Spo7p membrane complex. A mammalian ortholog of
Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly"
dullard"), but its Spo7p-like partner is unknown, and the need for its existence is debated …
cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated,
and the yeast ortholog Pah1p becomes membrane-associated and active upon
dephosphorylation by the Nem1p-Spo7p membrane complex. A mammalian ortholog of
Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly"
dullard"), but its Spo7p-like partner is unknown, and the need for its existence is debated …