[HTML][HTML] TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
F Van Hauwermeiren, RE Vandenbroucke, L Grine… - Mucosal …, 2015 - Elsevier
Tumor necrosis factor (TNF) is a powerful activator of the immune system and a well-
validated target for treatment of autoimmune diseases. Injection of TNF induces systemic
lethal inflammation characterized by hypothermia, induction of multiple cytokines, and
extensive damage to multiple organs. Previously, we reported that TNF-induced lethal
inflammation is strictly TNFR1 (P55)-dependent. We also uncovered a crucial role for P55
expression levels in intestinal epithelial cells (IECs), in which P55+/+ expression is sufficient …
validated target for treatment of autoimmune diseases. Injection of TNF induces systemic
lethal inflammation characterized by hypothermia, induction of multiple cytokines, and
extensive damage to multiple organs. Previously, we reported that TNF-induced lethal
inflammation is strictly TNFR1 (P55)-dependent. We also uncovered a crucial role for P55
expression levels in intestinal epithelial cells (IECs), in which P55+/+ expression is sufficient …