Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding
X Liu, MS Burhans, MT Flowers, JM Ntambi - Journal of hepatology, 2016 - Elsevier
Background & Aims High-carbohydrate diets contribute to the development of liver stress
and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of
monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD)
family of enzymes, in regulation of liver function during lipogenic dietary conditions remains
largely unknown. The major products of SCD-catalyzed reactions are oleate (18: 1n-9) and
palmitoleate (16: 1n-7). Methods We generated mouse models with restricted exogenous …
and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of
monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD)
family of enzymes, in regulation of liver function during lipogenic dietary conditions remains
largely unknown. The major products of SCD-catalyzed reactions are oleate (18: 1n-9) and
palmitoleate (16: 1n-7). Methods We generated mouse models with restricted exogenous …