[HTML][HTML] β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes

J Klein, M Fasshauer, M Ito, BB Lowell, M Benito… - Journal of Biological …, 1999 - ASBMB
Activity of the sympathetic nervous system is an important factor involved in the
pathogenesis of insulin resistance and associated metabolic and vascular abnormalities. In
this study, we investigate the molecular basis of cross-talk between β 3-adrenergic and
insulin signaling systems in mouse brown adipocytes immortalized by SV40 T infection.
Insulin-induced tyrosine phosphorylation of the insulin receptor, insulin receptor substrate 1
(IRS-1), and IRS-2 was reduced by prestimulation of β 3-adrenergic receptors (CL316243) …