[HTML][HTML] Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

N Li, K Ragheb, G Lawler, J Sturgis, B Rajwa… - Journal of Biological …, 2003 - ASBMB
Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce
cell death in a variety of cells. However, the mechanism is still elusive. Because reactive
oxygen species (ROS) play an important role in apoptosis and inhibition of mitochondrial
respiratory chain complex I by rotenone was thought to be able to elevate mitochondrial
ROS production, we investigated the relationship between rotenone-induced apoptosis and
mitochondrial reactive oxygen species. Rotenone was able to induce mitochondrial complex …