Paraquat modulates microglia M1/M2 polarization via activation of TLR4-mediated NF-κB signaling pathway
M Huang, Y Li, K Wu, W Yan, T Tian, Y Wang… - Chemico-biological …, 2019 - Elsevier
Paraquat (PQ) is a widely characterized neurotoxicant able to induce a series of nervous
system disorders, including neurobehavioral defects and neurodegenerative diseases.
Despite the direct evidence that PQ could induce inflammatory responses in central nervous
system and largely contribute to neurotoxicity, the putative adverse effects of PQ on the
neuroimmune interactions have rarely been investigated. Therefore, the present study
investigated underlying mechanisms of PQ-induced inflammatory response in BV-2 …
system disorders, including neurobehavioral defects and neurodegenerative diseases.
Despite the direct evidence that PQ could induce inflammatory responses in central nervous
system and largely contribute to neurotoxicity, the putative adverse effects of PQ on the
neuroimmune interactions have rarely been investigated. Therefore, the present study
investigated underlying mechanisms of PQ-induced inflammatory response in BV-2 …