Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cδ in dopaminergic neuronal cells
Oxidative stress is a key apoptotic stimulus in neuronal cell death and has been implicated
in the pathogenesis of many neurodegenerative disorders, including Parkinson disease
(PD). Recently, we demonstrated that protein kinase C-δ (PKCδ) is an oxidative stress-
sensitive kinase that can be activated by caspase-3-dependent proteolytic cleavage to
induce apoptotic cell death in cell culture models of Parkinson disease (Kaul, S.,
Kanthasamy, A., Kitazawa, M., Anantharam, V., and Kanthasamy, AG (2003) Eur. J …
in the pathogenesis of many neurodegenerative disorders, including Parkinson disease
(PD). Recently, we demonstrated that protein kinase C-δ (PKCδ) is an oxidative stress-
sensitive kinase that can be activated by caspase-3-dependent proteolytic cleavage to
induce apoptotic cell death in cell culture models of Parkinson disease (Kaul, S.,
Kanthasamy, A., Kitazawa, M., Anantharam, V., and Kanthasamy, AG (2003) Eur. J …
