Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal …
H Saminathan, A Asaithambi, V Anantharam… - Neurotoxicology, 2011 - Elsevier
Oxidative stress and apoptosis are two key pathophysiological mechanisms underlying
dopaminergic degeneration in Parkinson's disease (PD). Recently, we identified that
proteolytic activation of protein kinase C-delta (PKCδ), a member of the novel PKC family,
contributes to oxidative stress-induced dopaminergic degeneration and that phosphorylation
of tyrosine residue 311 (tyr311) on PKCδ is a key event preceding the PKCδ proteolytic
activation during oxidative damage. Herein, we report that a non-receptor tyrosine kinase …
dopaminergic degeneration in Parkinson's disease (PD). Recently, we identified that
proteolytic activation of protein kinase C-delta (PKCδ), a member of the novel PKC family,
contributes to oxidative stress-induced dopaminergic degeneration and that phosphorylation
of tyrosine residue 311 (tyr311) on PKCδ is a key event preceding the PKCδ proteolytic
activation during oxidative damage. Herein, we report that a non-receptor tyrosine kinase …