Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and …
MR Langley, S Ghaisas, M Ay, J Luo, BN Palanisamy… - Neurotoxicology, 2018 - Elsevier
Parkinson's disease (PD) is now recognized as a neurodegenerative condition caused by a
complex interplay of genetic and environmental influences. Chronic manganese (Mn)
exposure has been implicated in the development of PD. Since mitochondrial dysfunction is
associated with PD pathology as well as Mn neurotoxicity, we investigated whether Mn
exposure augments mitochondrial dysfunction and neurodegeneration in the nigrostriatal
dopaminergic system using a newly available mitochondrially defective transgenic mouse …
complex interplay of genetic and environmental influences. Chronic manganese (Mn)
exposure has been implicated in the development of PD. Since mitochondrial dysfunction is
associated with PD pathology as well as Mn neurotoxicity, we investigated whether Mn
exposure augments mitochondrial dysfunction and neurodegeneration in the nigrostriatal
dopaminergic system using a newly available mitochondrially defective transgenic mouse …
