[HTML][HTML] Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of …
H Jin, A Kanthasamy, DS Harischandra… - Journal of Biological …, 2014 - ASBMB
The oxidative stress-sensitive protein kinase Cδ (PKCδ) has been implicated in
dopaminergic neuronal cell death. However, little is known about the epigenetic
mechanisms regulating PKCδ expression in neurons. Here, we report a novel mechanism
by which the PKCδ gene can be regulated by histone acetylation. Treatment with histone
deacetylase (HDAC) inhibitor sodium butyrate (NaBu) induced PKCδ expression in cultured
neurons, brain slices, and animal models. Several other HDAC inhibitors also mimicked …
dopaminergic neuronal cell death. However, little is known about the epigenetic
mechanisms regulating PKCδ expression in neurons. Here, we report a novel mechanism
by which the PKCδ gene can be regulated by histone acetylation. Treatment with histone
deacetylase (HDAC) inhibitor sodium butyrate (NaBu) induced PKCδ expression in cultured
neurons, brain slices, and animal models. Several other HDAC inhibitors also mimicked …