Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of …
LS Lenz, J Marx, W Chamulitrat, I Kaiser… - Journal of Biological …, 2011 - jbc.org
Fatp4 exhibits acyl-CoA synthetase activity and is thereby able to catalyze the activation of
fatty acids for further metabolism. However, its actual function in most tissues remains
unresolved, and its role in cellular fatty acid uptake is still controversial. To characterize
Fatp4 functions in adipocytes in vivo, we generated a mouse line with adipocyte-specific
inactivation of the Fatp4 gene (Fatp4 A−/−). Under standard conditions mutant mice showed
no phenotypical aberrance. Uptake of radiolabeled palmitic and lignoceric acid into adipose …
fatty acids for further metabolism. However, its actual function in most tissues remains
unresolved, and its role in cellular fatty acid uptake is still controversial. To characterize
Fatp4 functions in adipocytes in vivo, we generated a mouse line with adipocyte-specific
inactivation of the Fatp4 gene (Fatp4 A−/−). Under standard conditions mutant mice showed
no phenotypical aberrance. Uptake of radiolabeled palmitic and lignoceric acid into adipose …