[HTML][HTML] Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low …
FAT/CD36 is a multifunctional glycoprotein that facilitates long-chain fatty acid (FA) uptake
by cardiomyocytes and adipocytes and uptake of oxidized low density lipoproteins (oxLDL)
by macrophages. CD36 also mediates FA-induced signaling to increase intracellular
calcium in various cell types. The membrane-impermeable sulfo-N-hydroxysuccinimidyl
(NHS) ester of oleate (SSO) irreversibly binds CD36 and has been widely used to inhibit
CD36-dependent FA uptake and signaling to calcium. The inhibition mechanism and …
by cardiomyocytes and adipocytes and uptake of oxidized low density lipoproteins (oxLDL)
by macrophages. CD36 also mediates FA-induced signaling to increase intracellular
calcium in various cell types. The membrane-impermeable sulfo-N-hydroxysuccinimidyl
(NHS) ester of oleate (SSO) irreversibly binds CD36 and has been widely used to inhibit
CD36-dependent FA uptake and signaling to calcium. The inhibition mechanism and …