Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake
MP Lambert, A Paliwal, T Vaissière, I Chemin… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is one of the most frequent
human cancers and a major cause of cancer-related death worldwide. The major risk factors
for developing HCC are infection by hepatitis B virus (HBV) and hepatitis C virus (HCV),
chronic alcoholism, and aflatoxins; however, critical gene targets remain largely unknown.
Herein, we sought to establish DNA methylation patterns in HCC and corresponding
cirrhotic tissues and to identify DNA methylation changes associated with major risk factors …
human cancers and a major cause of cancer-related death worldwide. The major risk factors
for developing HCC are infection by hepatitis B virus (HBV) and hepatitis C virus (HCV),
chronic alcoholism, and aflatoxins; however, critical gene targets remain largely unknown.
Herein, we sought to establish DNA methylation patterns in HCC and corresponding
cirrhotic tissues and to identify DNA methylation changes associated with major risk factors …