[HTML][HTML] Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
Background & Aims Human hepatocarcinogenesis is as a multi-step process starting from
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC).
However, the sequential molecular alterations driving malignant transformation of the pre-
neoplastic lesions are not clearly defined. This lack of information represents a major
challenge in the clinical management of patients at risk. Methods We applied next-
generation transcriptome sequencing to tumor-free surrounding liver (n= 7), low-(n= 4) and …
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC).
However, the sequential molecular alterations driving malignant transformation of the pre-
neoplastic lesions are not clearly defined. This lack of information represents a major
challenge in the clinical management of patients at risk. Methods We applied next-
generation transcriptome sequencing to tumor-free surrounding liver (n= 7), low-(n= 4) and …