Background & Aims The differentiation of distinct multifocal hepatocellular carcinoma (HCC):
multicentric disease vs. intrahepatic metastases, in which the management and prognosis
varies substantively, remains problematic. We aim to stratify multifocal HCC and identify
novel diagnostic and prognostic biomarkers by performing whole genome and transcriptome
sequencing, as part of a multi-omics strategy. Methods A complete collection of tumour and
somatic specimens (intrahepatic HCC lesions, matched non-cancerous liver tissue and …