Generation of effector CD8+ T cells and their conversion to memory T cells

W Cui, SM Kaech - Immunological reviews, 2010 - Wiley Online Library
Immunological reviews, 2010Wiley Online Library
Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to
acquire longevity, survive the effector‐to‐memory transition, and mature into multipotent,
functional memory T cells that self‐renew. Here, we discuss the recent findings in this area
and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T
cells.
Summary
Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector‐to‐memory transition, and mature into multipotent, functional memory T cells that self‐renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.
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