Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and …

AJ Boyle, H Shih, J Hwang, J Ye, B Lee, Y Zhang… - Experimental …, 2011 - Elsevier
Aging is associated with an increased incidence of heart failure, but the existence of an age-
related cardiomyopathy remains controversial. Differences in strain, age and technique of
measuring cardiac function differ between experiments, confounding the interpretation of
these studies. Additionally, the structural and genetic profile at the onset of heart failure has
not been extensively studied. We therefore performed serial echocardiography, which
allows repeated assessment of left ventricular (LV) function, on a cohort of the same mice …