Plasma membrane repair is an essential process for maintenance of homeostasis at the
cellular and tissue levels, whereas compromised repair capacity contributes to degenerative
human diseases. Our recent studies show that MG53 is essential for muscle membrane
repair, and defects in MG53 function are linked to muscular dystrophy and cardiac
dysfunction. Here we report that polymerase I and transcript release factor (PTRF), a gene
known to regulate caveolae membrane structure, is an indispensable component of the …