[HTML][HTML] The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
J Torchia, DW Rose, J Inostroza, Y Kamei, S Westin… - Nature, 1997 - nature.com
The functionally conserved proteins CBP and p300 act in conjunction with other factors to
activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the
cell as a complex with CBP and is required for transcriptional activity of nuclear receptors
and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-
activator protein NCoA-1 is also specifically required for ligand-dependent activation of
genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich …
activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the
cell as a complex with CBP and is required for transcriptional activity of nuclear receptors
and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-
activator protein NCoA-1 is also specifically required for ligand-dependent activation of
genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich …
Abstract
The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.
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