Conversion of xanthine dehydrogenase into xanthine oxidase in rat liver and plasma at the onset of reperfusion after ischemia

A Kooij, HJ Schiller, M Schijns, CJF Van Noorden… - Hepatology, 1994 - journals.lww.com
The aim of this study was to test whether conversion of xanthine dehydrogenase into
xanthine oxidase as induced by fasting, ischemia of the liver or both is an in vivo process or
only occurs in vitro in homogenates. For this purpose, the conversion rate of xanthine
dehydrogenase into xanthine oxidase was studied in liver homogenates obtained from rats
after normal feeding or 24 hr of fasting followed or not by 2 hr of ischemia of the liver. In fed
rats, the conversion rate of xanthine dehydrogenase into xanthine oxidase was studied as …