Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices
ME Lauer, J Loftis, C de la Motte, VC Hascall - … : Chemistry and Biology, 2014 - Springer
ME Lauer, J Loftis, C de la Motte, VC Hascall
Glycosaminoglycans: Chemistry and Biology, 2014•SpringerDuring inflammation and developmental processes, heavy chains (HCs) from inter-α-
inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-
factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. In this manuscript, we describe
a gel-based assay to detect HC-HA and TSG-6 activity in tissues.
inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-
factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. In this manuscript, we describe
a gel-based assay to detect HC-HA and TSG-6 activity in tissues.
Abstract
During inflammation and developmental processes, heavy chains (HCs) from inter-α-inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. In this manuscript, we describe a gel-based assay to detect HC-HA and TSG-6 activity in tissues.
Springer
