[HTML][HTML] Pleiotropic effects of cavin-1 deficiency on lipid metabolism

SY Ding, MJ Lee, R Summer, L Liu, SK Fried… - Journal of Biological …, 2014 - ASBMB
Mice and humans lacking caveolae due to gene knock-out or inactivating mutations of cavin-
1/PTRF have numerous pathologies including markedly aberrant fuel metabolism,
lipodystrophy, and muscular dystrophy. We characterized the physiologic/metabolic profile
of cavin-1 knock-out mice and determined that they were lean because of reduced white
adipose depots. The knock-out mice were resistant to diet-induced obesity and had
abnormal lipid metabolism in the major metabolic organs of white and brown fat and liver …