Purinergic transmission in blood vessels
V Ralevic, WR Dunn - Autonomic Neuroscience, 2015 - Elsevier
There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled
adenosine and P2Y receptors, and ionotropic P2X receptors. The majority are functionally
expressed in blood vessels, as purinergic receptors in perivascular nerves, smooth muscle
and endothelial cells, and roles in regulation of vascular contractility, immune function and
growth have been identified. The endogenous ligands for purine receptors, ATP, ADP, UTP …
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled
adenosine and P2Y receptors, and ionotropic P2X receptors. The majority are functionally
expressed in blood vessels, as purinergic receptors in perivascular nerves, smooth muscle
and endothelial cells, and roles in regulation of vascular contractility, immune function and
growth have been identified. The endogenous ligands for purine receptors, ATP, ADP, UTP …
