[HTML][HTML] Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
IKN Pettersen, D Tusubira, H Ashrafi, SE Dyrstad… - Mitochondrion, 2019 - Elsevier
Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production.
Regulation occurs through multiple nutrient-and energy-sensitive molecular mechanisms.
We explored if upregulated mRNA expression of the mitochondrial enzyme pyruvate
dehydrogenase kinase 4 (PDK4) may be used as a surrogate marker of increased
mitochondrial fatty acid oxidation, by indicating an overall shift from glucose to fatty acids as
the preferred oxidation fuel. The association between fatty acid oxidation and PDK4 …
Regulation occurs through multiple nutrient-and energy-sensitive molecular mechanisms.
We explored if upregulated mRNA expression of the mitochondrial enzyme pyruvate
dehydrogenase kinase 4 (PDK4) may be used as a surrogate marker of increased
mitochondrial fatty acid oxidation, by indicating an overall shift from glucose to fatty acids as
the preferred oxidation fuel. The association between fatty acid oxidation and PDK4 …