The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome

H Wang, S Ma - The American journal of emergency medicine, 2008 - Elsevier
Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in
intensive care units. It is being encountered frequently in critically ill patients owing to
advancements in organ-specific supportive technologies to survive the acute phase of
severe sepsis and shock. It is now believed that MODS is the result of an inappropriate
generalized inflammatory response of the host to a variety of acute insults. The pathologic
mechanisms of MODS were reviewed, and factors determining the sequence and severity of …