[HTML][HTML] The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists
M Rusnati, G Tulipano, C Urbinati, E Tanghetti… - Journal of Biological …, 1998 - ASBMB
Heparin binds extracellular HIV-1 Tat protein and modulates its HIV long terminal repeat
(LTR)-transactivating activity (M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini, D.
Noonan, F. d'Adda di Fagagna, M. Giacca, and M. Presta (1997) J. Biol. Chem. 272, 11313–
11320). On this basis, the glutathioneS-transferase (GST)-Tat R49/52/53/55/56/57A mutant,
in which six arginine residues within the basic domain of Tat were mutagenized to alanine
residues, was compared with GST-Tat for its capacity to bind immobilized heparin …
(LTR)-transactivating activity (M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini, D.
Noonan, F. d'Adda di Fagagna, M. Giacca, and M. Presta (1997) J. Biol. Chem. 272, 11313–
11320). On this basis, the glutathioneS-transferase (GST)-Tat R49/52/53/55/56/57A mutant,
in which six arginine residues within the basic domain of Tat were mutagenized to alanine
residues, was compared with GST-Tat for its capacity to bind immobilized heparin …