[HTML][HTML] Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells
F Semeraro, CT Ammollo, NL Esmon… - Journal of Thrombosis and …, 2014 - Elsevier
Background Extracellular histones exert part of their prothrombotic activity through the
stimulation of blood cells. Besides platelets, histones can bind to red blood cells (RBCs),
which are important contributors to thrombogenesis, but little is known about the functional
consequences of this interaction. Objectives To evaluate the effect of histones on the
procoagulant potential of human RBCs with particular regard to the expression of surface
phosphatidylserine (PS). Methods PS exposure on human RBCs treated with a natural …
stimulation of blood cells. Besides platelets, histones can bind to red blood cells (RBCs),
which are important contributors to thrombogenesis, but little is known about the functional
consequences of this interaction. Objectives To evaluate the effect of histones on the
procoagulant potential of human RBCs with particular regard to the expression of surface
phosphatidylserine (PS). Methods PS exposure on human RBCs treated with a natural …