Oxygen sensing by HIF hydroxylases

CJ Schofield, PJ Ratcliffe - Nature reviews Molecular cell biology, 2004 - nature.com
CJ Schofield, PJ Ratcliffe
Nature reviews Molecular cell biology, 2004nature.com
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown
that this factor is regulated by an unprecedented signalling mechanism that involves post-
translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-
dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily.
The absolute requirement of these enzymes for molecular oxygen has provided new insights …
Abstract
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.
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