Adipokine and cytokine profiles of epicardial and subcutaneous adipose tissue in patients with coronary heart disease

OV Gruzdeva, OE Akbasheva, YA Dyleva… - Bulletin of experimental …, 2017 - Springer
OV Gruzdeva, OE Akbasheva, YA Dyleva, LV Antonova, VG Matveeva, EG Uchasova…
Bulletin of experimental biology and medicine, 2017Springer
The content of adipokines, pro-and anti-inflammatory cytokines were studied in adipocytes
isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease
patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose
tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in
adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of
proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue …
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
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