Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs
Y Yamauchi, Y Miura, Y Kanaho - Advances in biological regulation, 2017 - Elsevier
Abstract The Small GTPase ADP-ribosylation factor 6 (Arf6) functions as the molecular
switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP-
bound active form, which is precisely regulated by two regulators, guanine nucleotide
exchange factors (GEFs) and GTPase-activating proteins (GAPs). Numerous studies have
shown that these machineries play critical roles in tumor angiogenesis/growth and cancer
cell invasion/metastasis through regulating the cycling of Arf6. Here, we summarize …
switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP-
bound active form, which is precisely regulated by two regulators, guanine nucleotide
exchange factors (GEFs) and GTPase-activating proteins (GAPs). Numerous studies have
shown that these machineries play critical roles in tumor angiogenesis/growth and cancer
cell invasion/metastasis through regulating the cycling of Arf6. Here, we summarize …
