[HTML][HTML] An antidiabetic Thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor Γ (PPARγ)∗

JM Lehmann, LB Moore, TA Smith-Oliver… - Journal of Biological …, 1995 - ASBMB
Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of
target tissues in animal models of non-insulin-dependent diabetes mellitus. In vitro,
thiazolidinediones promote adipocyte differentiation of preadipocyte and mesenchymal stem
cell lines; however, the molecular basis for this adipogenic effect has remained unclear.
Here, we report that thiazolidinediones are potent and selective activators of peroxisome
proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily …