[HTML][HTML] Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor α in a ligand-selective manner

MLR Hughes, B Liu, ML Halls, KM Wagstaff… - Journal of Biological …, 2015 - ASBMB
Nuclear hormone receptors (NHRs) regulate the expression of proteins that control aspects
of reproduction, development and metabolism, and are major therapeutic targets. However,
NHRs are ubiquitous and participate in multiple physiological processes. Drugs that act at
NHRs are therefore commonly restricted by toxicity, often at nontarget organs. For
endogenous NHR ligands, intracellular lipid-binding proteins, including the fatty acid-
binding proteins (FABPs), can chaperone ligands to the nucleus and promote NHR …