Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates
L Adam, R Le Grand, F Martinon - Electroporation Protocols: Preclinical …, 2014 - Springer
L Adam, R Le Grand, F Martinon
Electroporation Protocols: Preclinical and Clinical Gene Medicine, 2014•SpringerStrategies to improve vaccine efficacy are still required. The immunogenicity of DNA
vaccines is strongly improved by electroporation (EP). The skin is populated with a wide
variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe
a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates,
as a model for preclinical development of human vaccines, using noninvasive needleless
electrodes.
vaccines is strongly improved by electroporation (EP). The skin is populated with a wide
variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe
a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates,
as a model for preclinical development of human vaccines, using noninvasive needleless
electrodes.
Abstract
Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.
Springer
