Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion
D Rondas, A Tomas, M Soto-Ribeiro… - Journal of Biological …, 2012 - jbc.org
Actin cytoskeleton remodeling is well known to be positively involved in glucose-stimulated
pancreatic β cell insulin secretion. We have observed glucose-stimulated focal adhesion
remodeling at the β cell surface and have shown this to be crucial for glucose-stimulated
insulin secretion. However, the mechanistic link between such remodeling and the insulin
secretory machinery remained unknown and was the major aim of this study. MIN6B1 cells,
a previously validated model of primary β cell function, were used for all experiments. Total …
pancreatic β cell insulin secretion. We have observed glucose-stimulated focal adhesion
remodeling at the β cell surface and have shown this to be crucial for glucose-stimulated
insulin secretion. However, the mechanistic link between such remodeling and the insulin
secretory machinery remained unknown and was the major aim of this study. MIN6B1 cells,
a previously validated model of primary β cell function, were used for all experiments. Total …
