Interleukin-1 stimulates granule exocytosis from human neutrophils
RJ Smith, BJ Bowman, SC Speziale - International journal of …, 1986 - Elsevier
The interaction of human polymorphonuclear neutrophilic leukocytes (neutrophils) with
interleukin-1 (IL-1) resulted in a time-and concentration-dependent, selective, release of
azurophil (myeloperoxidase, lysozyme) and specific (lysozyme, vitamin B 12-binding
protein) granule constituents. Myeloperoxidase (MPO) and lysozyme secretion was
markedly attenuated if neutrophils were not exposed to cytochalasin B (CB) prior to contact
with IL-1. Degranulation was significantly enhanced in the presence of extracellular calcium …
interleukin-1 (IL-1) resulted in a time-and concentration-dependent, selective, release of
azurophil (myeloperoxidase, lysozyme) and specific (lysozyme, vitamin B 12-binding
protein) granule constituents. Myeloperoxidase (MPO) and lysozyme secretion was
markedly attenuated if neutrophils were not exposed to cytochalasin B (CB) prior to contact
with IL-1. Degranulation was significantly enhanced in the presence of extracellular calcium …