[HTML][HTML] Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and …
C Arous, PG Ferreira, ET Dermitzakis… - Journal of Biological …, 2015 - ASBMB
Type 2 diabetes involves defective insulin secretion with islet inflammation governed in part
by IL-1β. Prolonged exposure of islets to high concentrations of IL-1β (> 24 h, 20 ng/ml)
impairs beta cell function and survival. Conversely, exposure to lower concentrations of IL-
1β for> 24 h improves these same parameters. The impact on insulin secretion of shorter
exposure times to IL-1β and the underlying molecular mechanisms are poorly understood
and were the focus of this study. Treatment of rat primary beta cells, as well as rat or human …
by IL-1β. Prolonged exposure of islets to high concentrations of IL-1β (> 24 h, 20 ng/ml)
impairs beta cell function and survival. Conversely, exposure to lower concentrations of IL-
1β for> 24 h improves these same parameters. The impact on insulin secretion of shorter
exposure times to IL-1β and the underlying molecular mechanisms are poorly understood
and were the focus of this study. Treatment of rat primary beta cells, as well as rat or human …