[HTML][HTML] The optomotor response: a robust first-line visual screening method for mice
J Abdeljalil, M Hamid, O Abdel-Mouttalib, R Stéphane… - Vision research, 2005 - Elsevier
Vision research, 2005•Elsevier
In both scotopic and photopic conditions, the rotation of a grating was found to elicit head
movements in mice. The highest spatial frequency eliciting this optomotor response
provided an estimate of visual acuity. In male C57BL/6J mice, visual acuity increased from
0.26 cpd in scotopic conditions to 0.52 cpd in photopic conditions whereas it was 0.52 cpd in
both sets of conditions in 129/SvPas mice. No optomotor response was detected in albino
CD1 mice and rd1 retinal degeneration mice although light sensitivity in CD1 mice was …
movements in mice. The highest spatial frequency eliciting this optomotor response
provided an estimate of visual acuity. In male C57BL/6J mice, visual acuity increased from
0.26 cpd in scotopic conditions to 0.52 cpd in photopic conditions whereas it was 0.52 cpd in
both sets of conditions in 129/SvPas mice. No optomotor response was detected in albino
CD1 mice and rd1 retinal degeneration mice although light sensitivity in CD1 mice was …
In both scotopic and photopic conditions, the rotation of a grating was found to elicit head movements in mice. The highest spatial frequency eliciting this optomotor response provided an estimate of visual acuity. In male C57BL/6J mice, visual acuity increased from 0.26cpd in scotopic conditions to 0.52cpd in photopic conditions whereas it was 0.52cpd in both sets of conditions in 129/SvPas mice. No optomotor response was detected in albino CD1 mice and rd1 retinal degeneration mice although light sensitivity in CD1 mice was attested by photophobia and normal electroretinograms. This rapid and cheap method could provide a powerful test of visual performance in genetically modified and pharmacologically treated mice.
Elsevier