Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea

M Elger, H Hentschel, J Litteral, M Wellner… - Journal of the …, 2003 - journals.lww.com
The mammalian kidney responds to partial nephrectomy with glomerular and tubular
hypertrophy, but without renal regeneration. In contrast, renal regeneration in lower
vertebrates is known to occur. Understanding the underlying mechanisms of renal
regeneration is highly important; however, a serviceable animal model has not been
developed. A neonephrogenic zone has been identified in the European lesser spotted
dogfish, Scyliorhinus caniculus (Hentschel H. Am J Anat 190: 309–333, 1991), as well as in …