Alda-1 attenuates lung ischemia-reperfusion injury by reducing 4-hydroxy-2-nonenal in alveolar epithelial cells
J Ding, Q Zhang, Q Luo, Y Ying, Y Liu, Y Li… - Critical care …, 2016 - journals.lww.com
Objectives: Excessive oxidative stress is a main cause of lung ischemia-reperfusion injury,
which often results in respiratory insufficiency after open-heart surgery for a
cardiopulmonary bypass. Previous studies demonstrate that the activation of aldehyde
dehydrogenase-2 could significantly reduce the oxidative stress mediated by toxic
aldehydes and attenuate cardiac and cerebral ischemia-reperfusion injury. However, both
the involvement of aldehydes and the protective effect of the aldehyde dehydrogenase-2 …
which often results in respiratory insufficiency after open-heart surgery for a
cardiopulmonary bypass. Previous studies demonstrate that the activation of aldehyde
dehydrogenase-2 could significantly reduce the oxidative stress mediated by toxic
aldehydes and attenuate cardiac and cerebral ischemia-reperfusion injury. However, both
the involvement of aldehydes and the protective effect of the aldehyde dehydrogenase-2 …
