Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial
Importance Saline (0.9% sodium chloride) is the most commonly administered intravenous
fluid; however, its use may be associated with acute kidney injury (AKI) and increased
mortality. Objective To determine the effect of a buffered crystalloid compared with saline on
renal complications in patients admitted to the intensive care unit (ICU). Design and Setting
Double-blind, cluster randomized, double-crossover trial conducted in 4 ICUs in New
Zealand from April 2014 through October 2014. Three ICUs were general medical and …
fluid; however, its use may be associated with acute kidney injury (AKI) and increased
mortality. Objective To determine the effect of a buffered crystalloid compared with saline on
renal complications in patients admitted to the intensive care unit (ICU). Design and Setting
Double-blind, cluster randomized, double-crossover trial conducted in 4 ICUs in New
Zealand from April 2014 through October 2014. Three ICUs were general medical and …