Analysis of T cell receptor (TCR) data has become a crucial element in many studies aimed
at better understanding the evolution of the T cell repertoire and the role of TCR diversity in
immune responses. In this paper we focus on comparing the diversity between samples of
the TCR repertoire. We discuss some of the limitations and potential problems inherent in
some of the more popular approaches to comparing samples of the TCR repertoire and we
suggest alternate methods that both avoid these problems and enrich the analysis of TCR …