[HTML][HTML] Differential effects of transforming growth factor-β on the expression of collagenase-1 and collagenase-3 in human fibroblasts
JA Urı́a, MG Jiménez, M Balbı́n, JMP Freije… - Journal of Biological …, 1998 - ASBMB
Collagenase-3 (MMP-13) is a matrix metalloproteinase (MMP) originally identified in breast
carcinomas which is also produced at significant levels during fetal ossification and in
arthritic processes. In this work, we have found that transforming growth factor β1 (TGF-β1),
a growth factor widely assumed to be inhibitory for MMPs, strongly induces collagenase-3
expression in human KMST fibroblasts. In contrast, this growth factor down-regulated the
expression in these cells of collagenase-1 (MMP-1), an enzyme highly related to …
carcinomas which is also produced at significant levels during fetal ossification and in
arthritic processes. In this work, we have found that transforming growth factor β1 (TGF-β1),
a growth factor widely assumed to be inhibitory for MMPs, strongly induces collagenase-3
expression in human KMST fibroblasts. In contrast, this growth factor down-regulated the
expression in these cells of collagenase-1 (MMP-1), an enzyme highly related to …
