MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation
A Stacchini, M Aragno, A Vallario, A Alfarano… - Leukemia research, 1999 - Elsevier
We report the establishment and characterization of two cell lines, MEC1 and MEC2, that
grew spontaneously on two subsequent occasions from the peripheral blood (PB) of a
patient with B-chronic lymphocytic leukemia (B-CLL) in prolymphocytoid transformation. The
patient was EBV-seropositive, his leukemic cells were EBNA negative, but the
spontaneously grown cell lines are EBNA-2 positive. In liquid culture MEC1 cells grow
adherent to the vessel wall and as tiny clumps; MEC2 cells do not adhere and form large …
grew spontaneously on two subsequent occasions from the peripheral blood (PB) of a
patient with B-chronic lymphocytic leukemia (B-CLL) in prolymphocytoid transformation. The
patient was EBV-seropositive, his leukemic cells were EBNA negative, but the
spontaneously grown cell lines are EBNA-2 positive. In liquid culture MEC1 cells grow
adherent to the vessel wall and as tiny clumps; MEC2 cells do not adhere and form large …