Genetic factors of cervical spondylotic myelopathy-a systemic review
G Wang, Y Cao, T Wu, C Duan, J Wu, J Hu… - Journal of Clinical …, 2017 - Elsevier
G Wang, Y Cao, T Wu, C Duan, J Wu, J Hu, H Lu
Journal of Clinical Neuroscience, 2017•ElsevierBackground Cervical spondylotic myelopathy (CSM) is a degenerative disorder of the neck.
Recent studies have reported the roles of single nucleotide polymorphisms and abnormal
gene expression in the etiology and development of CSM. However, a systemic review of
these findings is currently unavailable. Methods A systemic review of genetic factors of CSM
was conducted through searching PubMed and EMbase databases. A total of 9 studies were
included in this study, which included 8 genes: brain derived neurotrophic factor (BDNF) …
Recent studies have reported the roles of single nucleotide polymorphisms and abnormal
gene expression in the etiology and development of CSM. However, a systemic review of
these findings is currently unavailable. Methods A systemic review of genetic factors of CSM
was conducted through searching PubMed and EMbase databases. A total of 9 studies were
included in this study, which included 8 genes: brain derived neurotrophic factor (BDNF) …
Background
Cervical spondylotic myelopathy (CSM) is a degenerative disorder of the neck. Recent studies have reported the roles of single nucleotide polymorphisms and abnormal gene expression in the etiology and development of CSM. However, a systemic review of these findings is currently unavailable.
Methods
A systemic review of genetic factors of CSM was conducted through searching PubMed and EMbase databases. A total of 9 studies were included in this study, which included 8 genes: brain derived neurotrophic factor (BDNF), osteopontin (OPN), bone morphogenic protein (BMP) 4, collagen IX, vitamin D receptor (VDR), apolipoprotein E (ApoE), hypoxia-inducible factor α (HIF-1α), and cyclooxygenase 2 (COX-2).
Results
The polymorphisms of 6 genes (OPN, BMP-4, collagen IX, VDR, HIF-1α) showed significant association with the susceptibility to or risk of CSM. The polymorphisms of 3 genes (BMP-4, ApoE4, HIF-1α) were significantly associated with the postoperative outcome. The polymorphism of BDNF, VDR, and expression of COX-2 were associated with the severity of disease.
Conclusion
This review demonstrates that 8 genes were associated with CSM although there is no repeated study. This review also suggests that large scale and high quality studies are needed to provide more reliable evidence for future evaluation.
Elsevier