Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
SK Bromley, SY Thomas, AD Luster - Nature immunology, 2005 - nature.com
SK Bromley, SY Thomas, AD Luster
Nature immunology, 2005•nature.comT cell circulation between peripheral tissues and the lymphoid compartment is critical for
immunosurveillance and host defense. However, the factors that determine whether T cells
remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate
that the chemokine receptor CCR7 is a critical signal that determines T cell exit from
peripheral tissue. Both CCR7− and CCR7+ effector T cells entered mouse asthmatic lung
and while CCR7− T cells accumulated, CCR7+ T cells continued to migrate into afferent …
immunosurveillance and host defense. However, the factors that determine whether T cells
remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate
that the chemokine receptor CCR7 is a critical signal that determines T cell exit from
peripheral tissue. Both CCR7− and CCR7+ effector T cells entered mouse asthmatic lung
and while CCR7− T cells accumulated, CCR7+ T cells continued to migrate into afferent …
Abstract
T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7− and CCR7+ effector T cells entered mouse asthmatic lung and while CCR7− T cells accumulated, CCR7+ T cells continued to migrate into afferent lymph. Delivery of both CCR7+ and CCR7− T cells directly into the airways showed that only CCR7+ T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues.
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