Granulysin: the attractive side of a natural born killer
E Sparrow, MD Bodman-Smith - Immunology letters, 2020 - Elsevier
First discovered in the 1980's, granulysin has until recently been thought of solely as an
effector molecule present within cytotoxic immune cell populations, and involved in the direct
killing of pathogens and infected or transformed eukaryotic cells. However, recent research
has suggested an additional role of granulysin, in particular the 15 kDa isoform. While 9 kDa
granulysin is broadly cytotoxic and capable of the direct killing of bacteria and other
pathogens, the 15 kDa isoform of this molecule has been shown to function as an immune …
effector molecule present within cytotoxic immune cell populations, and involved in the direct
killing of pathogens and infected or transformed eukaryotic cells. However, recent research
has suggested an additional role of granulysin, in particular the 15 kDa isoform. While 9 kDa
granulysin is broadly cytotoxic and capable of the direct killing of bacteria and other
pathogens, the 15 kDa isoform of this molecule has been shown to function as an immune …