[HTML][HTML] Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract
CM Posavad, L Zhao, L Dong, L Jin, CE Stevens… - Mucosal …, 2017 - Elsevier
Local mucosal cellular immunity is critical in providing protection from HSV-2. To
characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were isolated from
endocervical cytobrush and biopsy specimens from 17 HSV-2-infected women and
examined ex vivo for the expression of markers associated with maturation and tissue
residency and for functional T-cell responses to HSV-2. Compared with their circulating
counterparts, cervix-derived CD4+ and CD8+ T cells were predominantly effector memory T …
characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were isolated from
endocervical cytobrush and biopsy specimens from 17 HSV-2-infected women and
examined ex vivo for the expression of markers associated with maturation and tissue
residency and for functional T-cell responses to HSV-2. Compared with their circulating
counterparts, cervix-derived CD4+ and CD8+ T cells were predominantly effector memory T …